Praeruptorin A

CAS: 73069-25-7

Ref. TR-P699445

Product Information

• Name: Praeruptorin A
• Synonyms: 2-Butenoic acid, 2-methyl-, (9R,10R)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester, (2Z)-rel-, 2-Butenoic acid, 2-methyl-, 10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester, [9a(Z),10a]-(±)-, 2H,8H-Benzo[1,2-b:3,4-b']dipyran, 2-butenoic acid deriv., 2-Butenoic acid, 2-methyl-, 10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester, [9a(Z),10a]-, dl-Praeruptorin A, 2-Methyl-2-butenoic Acid [9a(Z),10a]-(±)-10-(Acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl Ester, 2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-butenoic Acid deriv., 2-Methyl-2-Butenoic Acid [9a(Z),10a]-10-(Acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl Ester, (-)-Pareruptorin A, Ccris 7247, (9R,10R)-10-(acetyloxy)-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-9-yl (2Z)-2-methylbut-2-enoate

Description

Applications Praeruptorin A is used in the treatment of cardiac diseases, extracted from Peucedani Radix, it exhibits anti-hypertensive effects. Also a potential anti-tumor agent due to the ability to modulate P-glycoprotein (Pgp), overexpression in MDR tumor cells.
References Song, Y. et al.: Molecules, 17, 4236 (2012); Shen, X. et al.: J. Pharm. Pharmacol., 64 90 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 386.40
• Formula: C₂₁H₂₂O₇
• Color/Form: Neat
• InChI: InChI=1S/C21H22O7/c1-6-11(2)20(24)27-19-18(25-12(3)22)16-14(28-21(19,4)5)9-7-13-8-10-15(23)26-17(13)16/h6-10,18-19H,1-5H3/b11-6-/t18-,19-/m0/s1
• InChI key: InChIKey=SNPBHOICIJUUFB-UHFFFAOYSA-N
• SMILES: CC(C)C(=O)C(C(=O)Nc1ccccc1)C(C(=O)c1ccc(F)cc1)c1ccccc1