Pregnenolone Carbonitrile

CAS: 1434-54-4

Ref. TR-P712240

Product Information

• Name: Pregnenolone Carbonitrile
• Synonyms: 3ß-Hydroxy-20-oxo-pregn-5-ene-16a-carbonitrile, 16a-Cyanopregnenolone, 3ß-Hydroxy-20-oxo-5-pregnen-16a-carbonitrile, 3ß-Hydroxy-20-oxopregn-5-ene-16a-carbonitrile, 5-Pregnen-3ß-ol-20-one-16a-carbonitrile, PCN, Pregn-5-ene-3ß-ol-20-oxo-16a-carbonitrile, Pregnenolone 16a-Carbonitrile, SC 4674, (3S,8S,9S,10R,13S,14S,16R,17S)-17-Acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile, (3Beta,16Alpha)-3-Hydroxy-20-Oxopregn-5-Ene-16-Carbonitrile, (3β,16α)-3-Hydroxy-20-oxopregn-5-ene-16-carbonitrile, 16α-Cyanopregnenolone, 3beta-Hydroxy-20-oxo-5-pregnene-16alpha-carbonitrile, 3β-Hydroxy-20-oxo-5-pregnen-16α-carbonitrile, 3β-Hydroxy-20-oxopregn-5-ene-16α-carbonitrile, Ccris 9224, Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3beta,16alpha)-, Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3β,16α)-, Pregn-5-ene-16α-carbonitrile, 3β-hydroxy-20-oxo-, Pregn-5-ene-3β-ol-20-oxo-16α-carbonitrile, Pregnenolone 16alpha-carbonitrile, Pregnenolone 16α-carbonitrile, Pregnenolone carbonitrile, Sc 4674

Description

Applications Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).
References Kliewer, S.A., et. al.: Cell, 92, 73 (1998); Savas, U., et. al.: Drug Metab. Dispos., 28, 529 (2000)

• Brand: TRC

Chemical properties

• Molecular weight: 341.49
• Formula: C₂₂H₃₁NO₂
• Color/Form: Neat
• InChI: InChI=1S/C10H9N3/c1-3-7-11-9(5-1)13-10-6-2-4-8-12-10/h1-8H,(H,11,12,13)
• InChI key: InChIKey=HMMPCBAWTWYFLR-UHFFFAOYSA-N
• SMILES: c1ccc(Nc2ccccn2)nc1