Pregnenolone Carbonitrile

CAS: 1434-54-4

Ref. TR-P712240

Product Information

• Name: Pregnenolone Carbonitrile
• Synonyms: 3β-Hydroxy-20-oxo-pregn-5-ene-16α-carbonitrile, 16α-Cyanopregnenolone, 3β-Hydroxy-20-oxo-5-pregnen-16α-carbonitrile, 3β-Hydroxy-20-oxopregn-5-ene-16α-carbonitrile, 5-Pregnen-3β-ol-20-one-16α-carbonitrile, PCN, Pregn-5-ene-3β-ol-20-oxo-16α-carbonitrile, Pregnenolone 16α-Carbonitrile, SC 4674, (3S,8S,9S,10R,13S,14S,16R,17S)-17-Acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
• Brand: TRC
• Description: Applications Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).References Kliewer, S.A., et. al.: Cell, 92, 73 (1998); Savas, U., et. al.: Drug Metab. Dispos., 28, 529 (2000)

Chemical properties

• Molecular weight: 341.49
• Formula: C₂₂H₃₁NO₂
• Color/Form: Neat
• InChI: InChI=1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
• InChI key: InChIKey=HMMPCBAWTWYFLR-UHFFFAOYSA-N
• SMILES: c1ccc(Nc2ccccn2)nc1