Product Information
Name:Puromycin Dihydrochloride
Controlled Product
Synonyms:
- (2S)-2-amino-N-[(2S,4S,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]-3-(4-methoxyphenyl)propanamide;hydrochloride
Brand:TRC
Description:Applications Puromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.References Pestka, S. et al.: Ann. Rev. Micromiol., 8, 1559 (1997); Dando, P.M. et al.: Biomed. Health Res., 13, 88 (1997); McDonald, J.K. et al.: J. Biol. Chem., 243, 2028 (1968);
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Chemical properties
Molecular weight:544.43
Formula:C22H29N7O5·xHCl
Color/Form:Neat
InChI:InChI=1S/C22H29N7O5.ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);1H/t14-,15+,16?,18-,22+;/m0./s1
InChI key:InChIKey=RXWNCPJZOCPEPQ-VJWOANPKSA-N
SMILES:COc1ccc(C[C@H](N)C(=O)NC2[C@@H](CO)O[C@@H](n3cnc4c(N(C)C)ncnc43)[C@H]2O)cc1
Technical inquiry about: Puromycin Dihydrochloride
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