Puromycin-D3 Dihydrochloride

CAS: 58-58-2

Ref. TR-P840322

Product Information

• Name: Puromycin-D3 Dihydrochloride
• Synonyms: (S)-2-amino-N-((2S,3S,4R,5R)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)-3-(4-(methoxy-d3)phenyl)propanamide dihydrochloride, Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, hydrochloride (1:2), Adenosine, 3′-(α-amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyl-, dihydrochloride, L-, Adenosine, 3′-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride, (S)-, Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride, CL 16,536

Description

Applications Puromycin-D3 Dihydrochloride is a labelled analogue of Puromycin Dihydrochloride (P840320), an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.
References Pestka, S. et al.: Ann. Rev. Micromiol., 8, 1559 (1997); Dando, P.M. et al.: Biomed. Health Res., 13, 88 (1997); McDonald, J.K. et al.: J. Biol. Chem., 243, 2028 (1968);

• Brand: TRC

Chemical properties

• Molecular weight: 474.53 + 2(36.46)
• Formula: C₂₂H₂₆D₃N₇O₅• 2(HCl)
• Color/Form: Neat
• InChI: InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1/i3D3
• InChI key: InChIKey=RXWNCPJZOCPEPQ-DUDBXOQZSA-N
• SMILES: [2H]C([2H])([2H])Oc1ccc(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@@H](n3cnc4c(N(C)C)ncnc43)[C@@H]2O)cc1