(+)-Quisqualic Acid

CAS: 52809-07-1

Ref. TR-Q825000

Product Information

• Name: (+)-Quisqualic Acid
• Synonyms: (2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid, (2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid, (2S)-2-Amino-3-(3-hydroxy-5-oxo-2,5-dihydro-1,2,4-oxadiazol-2-yl)propanoic acid, (2S)-2-Amino-3-(5-hydroxy-3-oxo-2,3-dihydro-1,2,4-oxadiazol-2-yl)propanoic acid, (αS)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid, 1,2,4-Oxadiazolidine-2-propanoic acid, alpha-amino-3,5-dioxo-, (S)-, 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (S)-, 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (αS)-, 3-(3,5-Dioxo-1,2,4-Oxadiazolidin-2-Yl)Alanine, 3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, <span class="text-smallcaps">L</span>-Quisqualic acid, Quisqualate, Quisqualinic acid, S-Quisqualic acid

Description

Applications An amino acid that is able to function as an agonist at multiple excitatory amino acid receptor substrates in the central nervous system. It also has high affinity for the kainate, AMPA and the metabotropic receptors. Inhibits the Ca2+/Cl-dependent glutamic acid uptake system in brain synaptic plasma membrane preparations.
References Honore, T., et al.: J. Neurochem., 38, 173 (1982), Schoepp, D., et al.: J. Neurochem., 50, 1605 (1988), Recasens, M., et al.: Neurochem. Int., 13, 463 (1988), Subasinghe, N., et al.: J. Med. Chem., 35, 4602 (1992)

• Brand: TRC

Chemical properties

• Molecular weight: 189.13
• Formula: C₅H₇N₃O₅
• Color/Form: Neat
• InChI: InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
• InChI key: InChIKey=ASNFTDCKZKHJSW-UHFFFAOYSA-N
• SMILES: NC(Cn1oc(=O)[nH]c1=O)C(=O)O