Product Information
Name:R406
Synonyms:
- 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one Monobenzenesulfonate
Brand:TRC
Description:Applications R406 is a potent Syk inhibitor which affects Dectin-1-mediated signalling in mammilian cells. R406 thus acts an anti-fungal agent. Also a potential anti-leukemia agent, through modulation of sphingosine-1 phosphate receptor 1 (S1PR1).References Borge, M. et al.: J. Immunol., 193, 3165 (2014); Kimura, Y. et al.: J. Biol. Chem., 289, 31565 (2014);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:470.45 + (158.18)
Formula:C22H23FN6O5·(C6H6O3S)
Color/Form:Light Brown
InChI:InChI=1S/C22H23FN6O5.C6H6O3S/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4;7-10(8,9)6-4-2-1-3-5-6/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30);1-5H,(H,7,8,9)
InChI key:InChIKey=UXDRJPYSTZHIOE-UHFFFAOYSA-N
SMILES:COc1cc(Nc2ncc(F)c(N=c3ccc4c([nH]3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC.O=S(=O)(O)c1ccccc1
Technical inquiry about: R406
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