Regadenoson

CAS: 313348-27-5

Ref. TR-R142800

Product Information

• Name: Regadenoson
• Synonyms: 2-[4-[(Methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine, CVT 3146, Lexiscan, 2-[4-(methylcarbamoyl)-1H-pyrazol-1-yl]adenosine, 6-Amino-2-[4-(methylcarbamoyl)-1H-pyrazol-1-yl]purine-9-yl-beta-D-ribofuranoside, Adenosine, 2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]-, Cv 3146, Cvt-3146, Nqz-021, Rapiscan

Description

Applications Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinson's and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3).
References (1) Gao, Z., et al.: J Pharmacol Exp Ther. 298, 209 (2001) (2) Yuan, G., et al.: Expert Opin Drug Discov. 10, 63 (2015) (3) Jackson, S., et al.: J Neurooncol. 126, 433 (2016)

• Brand: TRC

Chemical properties

• Molecular weight: 390.35
• Formula: C₁₅H₁₈N₈O₅
• Color/Form: Off White
• InChI: InChI=1S/C15H18N8O5/c1-17-13(27)6-2-19-23(3-6)15-20-11(16)8-12(21-15)22(5-18-8)14-10(26)9(25)7(4-24)28-14/h2-3,5,7,9-10,14,24-26H,4H2,1H3,(H,17,27)(H2,16,20,21)/t7-,9-,10-,14-/m1/s1
• InChI key: InChIKey=LZPZPHGJDAGEJZ-AKAIJSEGSA-N
• SMILES: CNC(=O)c1cnn(-c2nc(N)c3ncn([C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)c3n2)c1