Product Information
Name:Roxadustat Methyl Ester
Controlled Product
Synonyms:
- Methyl (4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycinate
- [(4-Hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-methyl Acetate
- FG-6488
- N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine Methyl Ester
Brand:TRC
Description:Applications Roxadustat Methyl Ester is used in the preparation of Roxadustat.Roxadustat (H948180) is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to increase white blood cell levels in blood and hematopoietic progenitor cells in bone marrow.It is used for treatment of anemia in patient with chronic kidney disease.References Wang, Z.: Faming Zhuanli Shenqing. 7 pp. (2018)Provenzano, R., et al.: J. Clin. Pharmacol. 60, 1432 (2020)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:366.367
Formula:C20H18N2O5
Color/Form:Neat
InChI:InChI=1S/C20H18N2O5/c1-12-16-10-14(27-13-6-4-3-5-7-13)8-9-15(16)19(24)18(22-12)20(25)21-11-17(23)26-2/h3-10,24H,11H2,1-2H3,(H,21,25)
InChI key:InChIKey=QSGJZCCNTOCDRI-UHFFFAOYSA-N
SMILES:COC(=O)CNC(=O)c1nc(C)c2cc(Oc3ccccc3)ccc2c1O
Technical inquiry about: Roxadustat Methyl Ester
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