Product Information
Name:RK 33
Controlled Product
Synonyms:
- 3,7-Dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one
Brand:TRC
Description:Applications RK 33 is an inhibitor of DDX3, an ATP-dependent RNA helicase (1). Aberrant regulation of DDX3 is related to various diseases such as prostate and breast cancer (2). RK 33 was shown to decrease proliferation of prostate cancer cells and induced a G1 phase cell-cycle arrest (2).References (1) Botlagunta, M. et al.: PLoS One. 6, e17563 (2011) (2) Xie, M., et al.: Cancer Res. 76, 6340 (2016)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:428.44
Formula:C23H20N6O3
Color/Form:Neat
InChI:InChI=1S/C23H20N6O3/c1-31-17-7-3-15(4-8-17)11-28-14-26-19-20-22(25-13-24-21(19)28)29(23(30)27-20)12-16-5-9-18(32-2)10-6-16/h3-10,13-14H,11-12H2,1-2H3
InChI key:InChIKey=COUMZXFUZDBRCZ-UHFFFAOYSA-N
SMILES:COc1ccc(Cn2c3ncnc4c(ncn4Cc4ccc(OC)cc4)c-3nc2=O)cc1
Technical inquiry about: RK 33
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