Roflumilast

CAS: 162401-32-3

Ref. TR-R639700

Product Information

• Name: Roflumilast
• Synonyms: 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide, B 9302-107, BY 217, BYK 20869, Daxas, Roflumilast,Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-, ARQ 151, Daliresp, Libertek
• Brand: TRC

Description

Applications Roflumilast is a selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.
References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001); Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001); Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002); Rabe, K.F., et al.: Lancet, 366, 563 (2005);

Chemical properties

• Molecular weight: 403.21
• Formula: C₁₇H₁₄Cl₂F₂N₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
• InChI key: InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N
• SMILES: O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1