Rolapitant Hydrochloride

CAS: 858102-79-1

Ref. TR-R639800

Product Information

• Name: Rolapitant Hydrochloride
• Synonyms: 1,7-Diazaspiro[4.5]decan-2-one, 8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-, hydrochloride (1:1), (5S,8S)-, 1,7-Diazaspiro[4.5]decan-2-one, 8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-, monohydrochloride, (5S,8S)- (9CI), Sch 619734, 1,7-Diazaspiro[4.5]decan-2-one, 8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-, hydrochloride (1:1), (5S,8S)-, 1,7-Diazaspiro[4.5]decan-2-one, 8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-, monohydrochloride, (5S,8S)-, Rolapitant hydrochloride

Description

Applications Rolapitant is an NK1 receptor antagonist that is used in the treatment of chemotherapy-induced nausea and vomiting.
References Rojas, C. et al.: Cancer Treat. Rev., 41, 904 (2015); Navari, R. et al.: Exp. Rev. Anticanc. Ther., 15, 1127 (2015);

• Brand: TRC

Chemical properties

• Molecular weight: 536.94
• Formula: C₂₅H₂₆F₆N₂O₂·ClH
• Color/Form: Neat
• InChI: InChI=1S/C25H26F6N2O2.ClH/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22;/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34);1H/t16-,22-,23-;/m1./s1
• InChI key: InChIKey=VEWAWEMXVUFANV-PVBCUUEWSA-N
• SMILES: C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl