Ruscogenin

CAS: 472-11-7

Ref. TR-R701750

Product Information

• Name: Ruscogenin
• Synonyms: (1β,3β,25R)-Spirost-5-ene-1,3-diol, (25R)-Spirost-5-ene-1β,3β-diol, 25D-Spirost-5-ene-1β,3β-diol, (1beta,3beta,22xi,25R)-spirost-5-en-1,3-diol, (1beta,3beta,25R)-spirost-5-en-1,3-diol, 25<span class="text-smallcaps">D</span>-Spirost-5-ene-1β,3β-diol, 25R-Ruscogenin, Ruscogenine, Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran], spirost-5-ene-1,3-diol deriv., Spirost-5-ene-1,3-diol, (1β,3β,25R)-, Spirost-5-ene-1β,3β-diol, (25R)-

Description

Applications A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner.
References Huang, Y. et al.: Drug Dev. Res., 69, 196 (2008); Huang, Y. et al.: J. Pharmacol. Sci., 108, 198 (2008); Song, J. et al.: J. Pharmacol. Sci., 113, 409 (2010);

• Brand: TRC

Chemical properties

• Molecular weight: 430.62
• Formula: C₂₇H₄₂O₄
• Color/Form: Neat
• InChI: InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI key: InChIKey=QMQIQBOGXYYATH-IDABPMKMSA-N
• SMILES: C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)C[C@@H](O)[C@]5(C)[C@H]4CC[C@@]32C)O[C@]12CC[C@@H](C)CO2