SANT-1

CAS: 304909-07-7

Ref. TR-S115000

Product Information

• Name: SANT-1
• Synonyms: (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine, (E)-N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine, 1-Piperazinamine, N-[(1E)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-

Description

Applications A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay).
References Chen, J.K., et al.: Proc. Natl. Acad. Sci. USA, 99, 14071 (2002), Frank-Kamenetsky, M., et al.: J. Biol. 1, 10 (2002)

• Brand: TRC

Chemical properties

• Molecular weight: 373.49
• Formula: C₂₃H₂₇N₅
• Color/Form: Neat
• InChI: InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
• InChI key: InChIKey=FOORCIAZMIWALX-JJIBRWJFSA-N
• SMILES: Cc1nn(-c2ccccc2)c(C)c1/C=N/N1CCN(Cc2ccccc2)CC1