Senecionine N-Oxide-D3

CAS: 13268-67-2

Ref. TR-S258657

Product Information

• Name: Senecionine N-Oxide-D3
• Synonyms: (3Z,5R,6R,14aR,14bR)-3-Ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione 12-Oxide-D3, 12-Hydroxy-senecionan-11,16-dione 4-Oxide-D3, NSC 106677-D3, Senecionine Oxide-D3, (3Z,5R,6R,14aR,14bR)-[partial]-3-Ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione 12-Oxide-D3
• Brand: TRC

Description

Stability Hygroscopic
Applications Senecionine N-oxide-D3 is a labelled analogue of Senecionine N-oxide (S258655Senecionine N-oxide is the major pyrrolizidine alkaloid in Senecio vulgaris, a native herb of the British Isles. Senecionine N-oxide is hepatotoxic, and is suspected to be an antifertility agent in rats. Despite its toxicity, it is also being regarded as an antiproliferative agent for tumour growth.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hartmann, T. & Toppel, G.: Phytochemistry, 26, 1639 (1987); Su, J., et al.: Org. Mag. Res., 11, 565 (1978); Tu, Z., et al.: J. Pharm. Sci., 77, 461 (1988)

Chemical properties

• Molecular weight: 354.41
• Formula: C₁₈H₂₂D₃NO₆
• Color/Form: Neat
• InChI: InChI=1S/C18H25NO6/c1-4-12-9-11(2)18(3,22)17(21)24-10-13-5-7-19(23)8-6-14(15(13)19)25-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4-/t11-,14-,15-,18-,19?/m1/s1/i3D3
• InChI key: InChIKey=PLGBHVNNYDZWGZ-OYLKOHBUSA-N
• SMILES: [2H]C([2H])([2H])[C@]1(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC(=O)/C(=C\C)C[C@H]1C)[C@@H]23