(10R)​- 6,​7,​10,​11-​Tetrahydro-​3-​(trifluoromethyl)​-​10-​[(2,​4,​5-​trifluorophenyl)​methyl]​-1,​2,​4-​triazolo[3,​4-​c]​[1,​4,​7]​triazecine-​8,​12(5H,​9H)​-​dione

CAS: 2088771-61-1

Ref. TR-S493150

Product Information

• Name: (10R)​- 6,​7,​10,​11-​Tetrahydro-​3-​(trifluoromethyl)​-​10-​[(2,​4,​5-​trifluorophenyl)​methyl]​-1,​2,​4-​triazolo[3,​4-​c]​[1,​4,​7]​triazecine-​8,​12(5H,​9H)​-​dione
• Synonyms: 1,2,4-Triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione, 6,7,10,11-tetrahydro-3-(trifluoromethyl)-10-[(2,4,5-trifluorophenyl)methyl]-, (10R)- (ACI), Sitagliptin Tablets Impurity FP-B (EP), (10R)-3-(Trifluoromethyl)-10-[(2,4,5-trifluorophenyl)methyl]-6,7,
• Brand: TRC
• Description: Applications (10R)-Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.References Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)

Chemical properties

• Molecular weight: 421.297
• Formula: C₁₆H₁₃F₆N₅O₂
• Color/Form: Off-White
• InChI: InChI=1S/C16H13F6N5O2/c17-9-6-11(19)10(18)4-7(9)3-8-5-12(28)23-1-2-27-13(14(29)24-8)25-26-15(27)16(20,21)22/h4,6,8H,1-3,5H2,(H,23,28)(H,24,29)/t8-/m1/s1
• InChI key: InChIKey=CJUCSNDPMOGZTM-MRVPVSSYSA-N
• SMILES: O=C1C[C@@H](Cc2cc(F)c(F)cc2F)NC(=O)c2nnc(C(F)(F)F)n2CCN1