SKF-525A Hydrochloride

CAS: 62-68-0

Ref. TR-S550000

Product Information

• Name: SKF-525A Hydrochloride
• Synonyms: Valeric acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester hydrochloride (6CI,8CI), 2-(Diethylamino)ethyl 2,2-diphenylvalerate hydrochloride, 2'-Diethylaminoethyl 2,2-diphenylpentanoate hydrochloride, Proadifen hydrochloride, RP 5171, SKF 525, SKF 525A, U 5446, Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1), Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester, hydrochloride (9CI), beta-Diethylaminoethyl diphenylpropylacetate hydrochloride, 2^′-Diethylaminoethyl 2,2-diphenylpentanoate hydrochloride, Benzeneacetic acid, α-phenyl-α-propyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1), Rp 5171, Skf 525, Skf 525A, Valeric acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester hydrochloride, β-Diethylaminoethyl diphenylpropylacetate hydrochloride

Description

Applications Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis.
References Boeynaems, J.M., et al.: Prostaglandins Leukotrienes Med., 25, 123 (1986), Khan, S., et al.: Biochem. Pharmacol., 45, 439 (1993), Salvemini, D., et al.: Br. J. Pharmacol., 108, 162 (1993), Satoh, T., et al.: J. Clin. Invest., 91, 409 (1993)

• Brand: TRC

Chemical properties

• Molecular weight: 389.96
• Formula: C₂₃H₃₁NO₂·ClH
• Color/Form: White To Beige
• InChI: InChI=1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3, /h7-16H,4-6,17-19H2,1-3H3, 1H
• InChI key: InChIKey=FHIKZROVIDCMJA-UHFFFAOYSA-N
• SMILES: CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c1ccccc1.Cl