Applications SMAD3 Inhibitor, SIS3 selectively inhibits TGF- and activin. It has been shown to reduce TGF-1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
References Jinnin, M., et al.: Mol. Pharmacol., 69, 597 (2006)