CAS 1009104-85-1

1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one

Formula: C₂₈H₂₇N₃O₃

InChI: InChI=1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3

InChI key: InChIKey=IJYPHMXWKKKHGT-UHFFFAOYSA-N

SMILES: C(=CC(=O)N1CC=2C(CC1)=CC(OC)=C(OC)C2)C3=C(N(C)C=4C3=CC=CN4)C5=CC=CC=C5

Synonyms:

• 2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-
• 1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one

1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one

CAS: 1009104-85-1

1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one

Formula: C₂₈H₂₇N₃O₃

Purity: 97%

Molecular weight: 453.54

Ref: 54-OR1054411

2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-

CAS: 1009104-85-1

Formula: C₂₈H₂₇N₃O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 453.5323

Ref: IN-DA00035Q

(E/Z)-SIS3 free base

CAS: 1009104-85-1

1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one

Formula: C₂₈H₂₇N₃O₃

Purity: 97%

Molecular weight: 453.53

Ref: IN-DG01391688

SMAD3 Inhibtor, SIS 3

Controlled Product

CAS: 1009104-85-1

Formula: C₂₈H₂₇N₃O₃

Color and Shape: Neat

Molecular weight: 453.532

Ref: TR-S564500

Smad3 Inhibitor, SIS3

CAS: 1009104-85-1

SIS3 is a Smad3 inhibitor that inhibits the transcriptional activity of Runx2. It has been shown to inhibit the expression of osteogenic genes in a transcription-polymerase chain reaction (PCR) assay. This drug also suppresses the growth of tumor cells, such as choroidal neovascularization induced by growth factor-β1 (GF-β1) and collagen production in lung fibroblasts and hepatocyte-like cells. SIS3 has been shown to be effective against cancerous tumors, including breast cancer, lung cancer, and melanoma. This drug binds to the polymerase chain reaction (PCR) site on DNA and blocks transcription. The binding of SIS3 leads to an increase in phosphatase activity and a decrease in lb-100 activity, which inhibits cell proliferation.

Formula: C₂₈H₂₇N₃O₃

Purity: Min. 95%

Molecular weight: 453.53 g/mol

Ref: 3D-JQB10485

(Rac)-SIS3 free base

CAS: 1009104-85-1

(Rac)-SIS3 free base blocks Smad3 signaling, lowering ADAMTS-5 and raising miRNA-140 in chondrocytes, suppressing TGF-β1–Smad3–driven podocyte EMT, and reducing activin A–induced MHSteC proliferat

Formula: C₂₈H₂₇N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 453.5323

Ref: TM-T12923