Spironolactone-d3

CAS: 52-01-7

Ref. TR-S683003

Product Information

• Name: Spironolactone-d3
• Synonyms: (7a,7a)-7-(Acetylthyo-d3)-17-hydroxy-3-oxopregn-4-one-21-carboxylic Acid ?-Lactone, 7a-Acetylthio-d3-3-oxo-17a-pregn-4-ene-21,17-carbolactone, SC-9420, Adactone, S-((2'R,7R,8R,9S,10R,13S,14S)-10,13-Dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate-d3, (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone, 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate, 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate, 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate, 3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone, 3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone, 3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone, 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-, 7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone, 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone, Abbolactone, Aldace, Aldactone, Aldactone A, Aldopur, Almatol, Altex, Aquareduct, Berlactone, Deverol, Diatensec, Dira, Duraspiron, Espironolactona, Euteberol, Lacalmin, Lacdene, Laractone, Nefurofan, Novo-Spiroton, Nsc 150399, Osiren, Osyrol, Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-, Quimolactona, S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate, S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate, S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate, Sagisal, Sc 9420, Sincomen, Spiresis, Spiretic, Spiridon, Spiro-Tablinen, Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv., Spiroctan, Spiroderm, Spirolactone, Spirolang, Spirolone, Spirone, Spironol, Spironolacton, Spironolactone A, Supra-Puren, Suracton, Uractone, Urusonin, Verospiron, Verospirone, Xenalon, carbolactone

Description

Applications Spironolactone-d3 is the labeled analogue of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975)

• Brand: TRC

Chemical properties

• Molecular weight: 419.59
• Formula: C₂₄H₂₉D₃O₄S
• Color/Form: Yellow Solid
• InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1/i1D3
• InChI key: InChIKey=LXMSZDCAJNLERA-OFUZVNSWSA-N
• SMILES: [2H]C([2H])([2H])C(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@@H]21