N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate

CAS: 3031-95-6

Ref. TR-S688795

Product Information

• Name: N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate
• Synonyms: N-[[5-Amino-1-(5-O-phosphono-ß-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic Acid, N-[(5-Amino-1-ß-D-ribofuranosylimidazol-4-yl)carbonyl]-, 3031-95-6, 5-Amino-4-imidazole-N-succinocarboxamide ribonucleotide, 5-Amino-N-(1,2-dicarboxyethyl)-1-ribofuranosylimidazole-4-carboxamide 5'-Phosphate, <span class="text-smallcaps">L</smallcap>-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-<smallcap>D</span>-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-, Aspartic acid, N-[(5-amino-1-β-<span class="text-smallcaps">D</smallcap>-ribofuranosylimidazol-4-yl)carbonyl]-, 5′-(dihydrogen phosphate), <smallcap>L</span>-, L-aspartic acid, N-[[5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-, N-(5-Amino-1-ribofuranosylimidazol-4-ylcarbonyl)aspartic acid 5′-phosphate, N-[(5-Amino-1-ribofuranosylimidazol-4-yl)carbonyl]aspartic Acid 5'-Phosphate, N-[5-Amino-1-(5'-phosphoribofuranosyl)-4-imidazolecarbonyl]aspartic Acid, N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic Acid, N-[[5-Amino-1-(5-O-phosphono-β-<span class="text-smallcaps">D</smallcap>-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-<smallcap>L</span>-aspartic acid, Saicar, Succino-AICAR

Description

Applications N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate is a metabolite of Purine. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

• Brand: TRC

Chemical properties

• Molecular weight: 454.28
• Formula: C₁₃H₁₉N₄O₁₂P
• Color/Form: Neat
• InChI: InChI=1S/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1
• InChI key: InChIKey=NAQGHJTUZRHGAC-ZZZDFHIKSA-N
• SMILES: Nc1c(C(=O)N[C@@H](CC(=O)O)C(=O)O)ncn1[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O