Sulbutiamine

CAS: 3286-46-2

Ref. TR-S689250

Product Information

• Name: Sulbutiamine
• Synonyms: Propanoic acid, 2-methyl-, 1,1'-[dithiobis[3-[1-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]ethylidene]-3,1-propanediyl]] ester, Isobutyric acid, diester with N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methylvinylene]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide] (7CI,8CI), Propanoic acid, 2-methyl-, dithiobis[3-[1-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]ethylidene]-3,1-propanediyl] ester (9CI), Formamide, N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methylvinylene]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-, diisobutyrate (ester) (8CI), Arcalion Forte, Bisibuthiamine, Bisibutiamine, O-Isobutyroylthiamine disulfide, O-Isobutyrylthiamine disulfide, Vitaberin, Arcalion, Bis(1-(2-isobutyryloxyethyl)-2-(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamido)-1-propenyl)disulfid, Bis(1-(4-amino-2-methyl-5-pyrimidinyl)-2-formyl-3,9-dimethyl-8-oxo-2-aza-7-oxa-3-decen-4-yl)disulfid, Bisibutiamin, Brn 0741531, Formamide, N,N'-(dithiobis(2-(2-hydroxyethyl)-1-methylvinylene))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-, diisobutyrate (ester), Isobutyric acid, diester with N,N′-[dithiobis[2-(2-hydroxyethyl)-1-methylvinylene]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide], N,N'-(Dithiobis(2-(2-hydroxyethyl)-1-methylvinylene))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide) diisobutyrate (ester), O,O'-Diisobutyrylthiamine disulfide, Propanoic acid, 2-methyl-, 1,1′-[dithiobis[3-[1-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]ethylidene]-3,1-propanediyl]] ester, Propanoic acid, 2-methyl-, dithiobis(3-(1-(((4-amino-2-methyl-5-pyrimidinyl)methyl)formylamino)ethylidene)-3,1-propanediyl) ester, Sulbutiamina, Sulbutiamina [INN-Spanish], Sulbutiaminum, Sulbutiaminum [INN-Latin], Thiamine disulfide O,O-diisobutyrate, Unii-42Ncm1Bw43, disulfanediylbis(2E)-2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}pent-2-ene-3,5-diyl bis(2-methylpropanoate)

Description

Applications Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine used for the treatment of asthenia and other related pathological conditions. Sulbutiamine is available over-the-counter in several countries as a component of nutritional supplements.
References Micheau, J., et al.: Pharmacol. Biochem. Behav., 23, 195 (1985), Bettendorff, L., et al.: Biochem. Pharmacol., 40, 2557 (1990), van Reeth, O., et al.: Drugs Today, 35, 187 (1999),

• Brand: TRC

Chemical properties

• Molecular weight: 702.89
• Formula: C₃₂H₄₆N₈O₆S₂
• Color/Form: Off White
• InChI: InChI=1S/C32H46N8O6S2/c1-19(2)31(43)45-11-9-27(21(5)39(17-41)15-25-13-35-23(7)37-29(25)33)47-48-28(10-12-46-32(44)20(3)4)22(6)40(18-42)16-26-14-36-24(8)38-30(26)34/h13-14,17-20H,9-12,15-16H2,1-8H3,(H2,33,35,37)(H2,34,36,38)/b27-21-,28-22-
• InChI key: InChIKey=CKHJPWQVLKHBIH-ZDSKVHJSSA-N
• SMILES: C/C(=C(\CCOC(=O)C(C)C)SS/C(CCOC(=O)C(C)C)=C(/C)N(C=O)Cc1cnc(C)[nH]c1=N)N(C=O)Cc1cnc(C)[nH]c1=N