N-Succinimidoxycarbonyl-Beta-alanine N-Succinimidyl Ester 1,4- Dioxane complex

CAS: 1215667-16-5

Ref. TR-S689850

Product Information

• Name: N-Succinimidoxycarbonyl-Beta-alanine N-Succinimidyl Ester 1,4- Dioxane complex
• Synonyms: 1,4-dioxane;(2,5-dioxopyrrolidin-1-yl) 3-[(2,5-dioxopyrrolidin-1-yl)oxycarbonylamino]propanoate
• Brand: TRC

Description

Applications A short, amino reactive homobifunctional crosslinking reagent. Crosslinking distance 8.3 Å. It is useful in polymer coupling to proteins, because it may lead to a better selectivity among all the amino groups present in a protein, thus yielding less heterogeneous PEG-protein conjugates mixture because only the most nucleophilic and solvent exposed amines can react.
References Gross, H., et al.: Tetrahedron, 24, 6935 (1968), Clark, R., et al.: J. Biol. Chem., 271, 21969 (1996), Guiotto, A., et al.: Bioorg. Med. Chem., 12, 5031 (2004),

Chemical properties

• Molecular weight: 415.35
• Formula: C₁₂H₁₃N₃O₈·C₄H₈O₂
• Color/Form: Neat
• InChI: InChI=1S/C12H13N3O8.C4H8O2/c16-7-1-2-8(17)14(7)22-11(20)5-6-13-12(21)23-15-9(18)3-4-10(15)19;1-2-6-4-3-5-1/h1-6H2,(H,13,21);1-4H2
• InChI key: InChIKey=AQUFMAPQJCPCRK-UHFFFAOYSA-N
• SMILES: C1COCCO1.O=C(CCNC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O