(R)-Sulindac

CAS: 190967-68-1

Ref. TR-S699205

Product Information

• Name: (R)-Sulindac
• Synonyms: (1Z)-5-Fluoro-2-methyl-1-[[4-[(R)-methylsulfinyl]phenyl]methylene]-1H-indene-3-acetic Acid, R-Sulindac Sulfoxide

Description

Applications (R)-Sulindac is the R-epimer metabolite of Sulinac (S699215). (S)-Sulindac increases the activity of the P 450 system better than (R)-Sulindac, but both epimers increase primarily the enzymes that oxidize (R)-Sulindac.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Duggan, D., et al.: J. Pharmacol. Exp. Ther., 1977, 201, 8 (1977), Hamman, M., et al.: Biochem. Pharmacol., 60, 7 (2000), Grimaud, R., et al.: J. Biol. Chem., 276, 48915 (2001),

• Brand: TRC

Chemical properties

• Molecular weight: 356.41
• Formula: C₂₀H₁₇FO₃S
• Color/Form: Neat
• InChI: InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-/t25-/m1/s1
• InChI key: InChIKey=MLKXDPUZXIRXEP-LQVWSKNFSA-N
• SMILES: CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc([S@@](C)=O)cc1