Product Information
Name:Sulindac Sulfide
Synonyms:
- (Z)-2-{5-Fluoro-2-methyl-1-[4-(methylthio)benzylidene]-1H-inden-3-yl}acetic acid
- Sulindac Sulphane
Brand:TRC
Description:Stability HygroscopicApplications An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.References Hermann, C., et al.: Oncogene, 17, 1769 (1998), Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999), Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000),
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:340.41
Formula:C20H17FO2S
Color/Form:Yellow-Orange
InChI:InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChI key:InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N
SMILES:CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1
Technical inquiry about: Sulindac Sulfide
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