Terbinafine Dimer Impurity Dihydrochloride Salt

CAS: 934365-23-8

Ref. TR-T107510

Product Information

• Name: Terbinafine Dimer Impurity Dihydrochloride Salt
• Synonyms: (2E,4E)-4-(4,4-Dimethyl-2-pentyn-1-ylidene)-N1,N5-dimethyl-N1,N5-bis(1-naphthalenylmethyl)-2-pentene-1,5-diamine Dihydrochloride Salt
• Brand: TRC

Description

Impurity Terbinafine EP Impurity E Dihydrochloride Salt
Applications A Terbinafine dimeric impurity of the antifungal agent Terbinafine (T107500), an orally active, antimycotic allylamine related to Naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. Antifungal. Also an impurity of SF 86-327 an antimycotic agent (2).
References 1. Petranyi G. et al.: Science. 1984 Jun 15;224(4654):1239-41. 2. Ryder, N et al.: Antimicrob Agents Chemother. 1985 Feb;27(2):252-6.

Chemical properties

• Molecular weight: 573.64
• Formula: C₃₆H₄₀N₂·2HCL
• Color/Form: Neat
• InChI: InChI=1S/C36H40N2.2ClH/c1-36(2,3)24-12-14-29(26-38(5)28-33-21-11-19-31-17-7-9-23-35(31)33)15-13-25-37(4)27-32-20-10-18-30-16-6-8-22-34(30)32;;/h6-11,13-23H,25-28H2,1-5H3;2*1H/b15-13+,29-14+
• SMILES: CN(C/C=C/C(=C\C#CC(C)(C)C)CN(C)Cc1cccc2ccccc12)Cc1cccc2ccccc12