a,a,a’,a’-Tetramethyl-5-methyl-1,3-benzenediacetonitrile

CAS: 120511-72-0

Ref. TR-T303615

Product Information

• Name: a,a,a’,a’-Tetramethyl-5-methyl-1,3-benzenediacetonitrile
• Synonyms: Anastrozole Imp. H (EP), Anastrozole USP Related Compound A, Anastrozole USP RC A, 1,3-Benzenediacetonitrile, alpha,alpha,alpha',alpha',5-pentamethyl-, 2,2'-(5-Methyl-1,3-phenylene)di(2-methylpropionitrile), 2-[3-(Cyanodimethylmethyl)-5-methylphenyl]-2-methylpropionitrile, 3,5-Bis(2-cyano-2-methylethyl)toluene, 3,5-Bis(2-cyanoprop-2-yl)toluene, Anastrozole Related Compound A, Anastrozole Impurity H, 1,3-Benzenediacetonitrile, α,α,α′,α′,5-pentamethyl-, 1,3-Benzenediacetonitrile, α¹,α¹,α³,α³,5-pentamethyl-, 2,2'-(5-Methyl-1,2-Phenylene)-Di(2-Methylpropiononitrile), 2,2'-(5-Methyl-1,3-phenylene)-di-(2-methylpronitrile), 2,2'-(5-Methyl-m-phenylene)bis-(2-methyl-propionitrile), 2,2'-(5-Methylbenzene-1,3-Diyl)Bis(2-Methylpropanenitrile), 2,2-(5-Methyl-1,3-Phenylene)-Bis-(2-Methyl-Propionitrile), 2,2-(5-Methyl-1,3-phenylene)di(2-methylpro piononitrice), 2,2′-(5-Methyl-1,3-phenylene)bis(2-methylpropanenitrile), 2-[3-(2-Cyanopropan-2-yl)-5-methylphenyl]-2-methylpropanenitrile, 3,3'-(5-Methylbenzene-1,3-Diyl)Dibutanenitrile, 3,5-Bis(2-Cyanoprop-2-Yl)Toluene, 3,5-Bis[2-cyanoisopropyl]toluene, α,α,α',α'-5-Pentamethyl-1,3-benzenediacetonitrile, α¹,α¹,α³,α³,5-Pentamethyl-1,3-benzenediacetonitrile

Description

Impurity Anastrozole EP Impurity H
Applications α,α,α’,α’-Tetramethyl-5-methyl-1,3-benzenediacetonitrile (Anastrozole EP Impurity H) is an intermediate in the synthesis of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.
References Jackson, T., et al.: Org. Biomolec. Chem., 5, 3368 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 226.32
• Formula: C₁₅H₁₈N₂
• Color/Form: White To Yellow
• InChI: InChI=1S/C15H18N2/c1-11-6-12(14(2,3)9-16)8-13(7-11)15(4,5)10-17/h6-8H,1-5H3
• SMILES: Cc1cc(C(C)(C)C#N)cc(C(C)(C)C#N)c1