(S)-Alpha,Alpha-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol

CAS: 848821-61-4

Ref. TR-T303850

Product Information

• Name: (S)-Alpha,Alpha-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol
• Synonyms: (S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine, (2S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsiloxy)methyl]pyrrolidine
• Brand: TRC

Description

Applications (S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol, is a diarylprolinol silyl ether organocatalyst. It is able to catalyze a variety of bond-forming reactions such as C-C, C-N, C-O, C-S, and C-Hal in high yields and excellent levels of enantiocontrol.
References Jensen KL, et al. Accounts of Chemical Research 45(2), 248-264, (2011);

Chemical properties

• Molecular weight: 597.51
• Formula: C₂₄H₂₃F₁₂NOSi
• Purity: >85%
• Color/Form: Neat
• InChI: InChI=1S/C24H23F12NOSi/c1-39(2,3)38-20(19-5-4-6-37-19,13-7-15(21(25,26)27)11-16(8-13)22(28,29)30)14-9-17(23(31,32)33)12-18(10-14)24(34,35)36/h7-12,19,37H,4-6H2,1-3H3/t19-/m0/s1
• InChI key: InChIKey=MOHRGTBNEJKFMB-IBGZPJMESA-N
• SMILES: C[Si](C)(C)OC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H]1CCCN1