Tetrandrine

CAS: 518-34-3

Ref. TR-T305785

Product Information

• Name: Tetrandrine
• Synonyms: 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-, Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1beta)-, Tetrandrine (6CI,7CI,8CI), (S,S)-Tetrandrine, 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, [4aS-(4aR*,16aR*)]-, Fanchinine, Hanfangchin A, NSC 77037, S,S-(+)-Tetrandrine, Sinomenine A, TTD, Tetrandrin, d-Tetrandrine, (+)-Tetrandrine, (1Beta)-6,6',7,12-Tetramethoxy-2,2'-Dimethylberbaman, (1Beta,1'Xi)-6,6',7,12-Tetramethoxy-2,2'-Dimethylberbaman, (4aS,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-, 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, [4aS-(4aR*,16aR*)]-, 6,6',7,12-Tetramethoxy-2,2'-dimethyl-1-beta-berbaman, Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1beta)-, Berbaman, 6,6′,7,12-tetramethoxy-2,2′-dimethyl-, (1β)-, D-Tetrandrine

Description

Applications Tetrandrine is a lipopolysaccharide-induced microglial suppressor, effectively reducing the production of bacterial inflammatory mediators. Anti-inflammatory, anti-nociceptive. Tetrandrine is used in China to treat high blood pressure. This drug blocked the TPC2 calcium channel required for the Ebola infection process (Robert A. Davey et al., Science 2015, DOI: 10.1126/science.1258758).
References Yalong, D. et al.: PLoS One. 9, e102522 (2014); Westra, I. et al.: PLoS One., 9, e95462 (2014); Chem. and Eng. News, 93 (9) 8 Mar.2 (2015)

• Brand: TRC

Chemical properties

• Molecular weight: 622.75
• Formula: C₃₈H₄₂N₂O₆
• Color/Form: Light Yellow Solid
• InChI: InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
• InChI key: InChIKey=SWMBOMMGMHMOHE-MXHYOXNLSA-N
• SMILES: OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO