3,4,5,6-Tetrahydrouridine (>80%)

CAS: 18771-50-1

Ref. TR-T310250

Product Information

• Name: 3,4,5,6-Tetrahydrouridine (>80%)
• Synonyms: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one, 1-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone, 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-, 3,4,5,6-Tetrahydrouridine, 4-hydroxy-1-(beta-D-ribofuranosyl)tetrahydropyrimidin-2(1H)-one, 4-hydroxy-1-pentofuranosyltetrahydropyrimidin-2(1H)-one, 5,6-Dihydrouridine, Brn 0752319, Nsc 112907, Nsc-112907-D, U 23284, Uridine, 3,4,5,6-tetrahydro-, Tetrahydrouridine, 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-β-D-ribofuranosyl-, 1-(β-D-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone

Description

Stability Light Sensitive
Applications 3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Funamizu, N., PLoS One, 37424 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 248.23
• Formula: C₉H₁₆N₂O₆
• Purity: >80%
• Color/Form: Neat
• InChI: InChI=1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
• InChI key: InChIKey=UCKYOOZPSJFJIZ-XVKVHKPRSA-N
• SMILES: O=C1NC(O)CCN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O