Product Information
Name:TH-302
Controlled Product
Synonyms:
- N,N'-Bis(2-bromoethyl)phosphorodiamidic Acid (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl Ester
Brand:TRC
Description:Applications TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard. Studies have shown that TH-302 treatment exhibited hypoxia-selective cytotoxicity and DNA damage in human cancer cellReferences Meng, F. et al.: Mol. Cancer Ther., 11, 740 (2012); Liu, Q. et al.: Cancer Chemother. Pharmacol., 69, 1487 (2012); Sun, J.D. et al.: Clin. Cancer Res., 18, 758 (2012);
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Chemical properties
Molecular weight:449.04
Formula:C9H16Br2N5O4P
Color/Form:Neat
InChI:InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19)
SMILES:Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+](=O)[O-]
Technical inquiry about: TH-302
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