bis(Thiazol-5-ylmethyl) ((2R,5R)-1,6-Diphenylhexane-2,5-diyl)dicarbamate

CAS: 1004316-56-6

Ref. TR-T345125

Product Information

• Name: bis(Thiazol-5-ylmethyl) ((2R,5R)-1,6-Diphenylhexane-2,5-diyl)dicarbamate
• Synonyms: Carbamic acid, N,N'-[(1R,4R)-1,4-bis(phenylmethyl)-1,4-butanediyl]bis-, C,C'-bis(5-thiazolylmethyl) ester, (2R,5R)-1,6-Diphenyl-2,5-bis[thiazol-5-ylmethoxycarbonylamino]hexane
• Brand: TRC
• Description: Applications bis(Thiazol-5-ylmethyl) ((2R,5R)-1,6-Diphenylhexane-2,5-diyl)dicarbamate is an impurity of Cobicistat (C633150), a HIV protease inhibitor that has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer.References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012)

Chemical properties

• Molecular weight: 550.69
• Formula: C₂₈H₃₀N₄O₄S₂
• Color/Form: Neat
• InChI: InChI=1S/C28H30N4O4S2/c33-27(35-17-25-15-29-19-37-25)31-23(13-21-7-3-1-4-8-21)11-12-24(14-22-9-5-2-6-10-22)32-28(34)36-18-26-16-30-20-38-26/h1-10,15-16,19-20,23-24H,11-14,17-18H2,(H,31,33)(H,32,34)/t23-,24-/m1/s1
• InChI key: InChIKey=ZCOYISSPYCHCMQ-DNQXCXABSA-N
• SMILES: O=C(N[C@H](CC[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1)OCc1cncs1