Estimated delivery in United States, on Thursday 23 Jan 2025
Product Information
Name:
(R)-(+)-Thiolactomycin
Controlled Product
Synonyms:
- (5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]thiophen-2-one
- (+)-Thiolactomycin
- (5R)-4-Hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadien-1-yl]-2(5H)-thiophenone
- 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-, [R-(E)]-
- 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadien-1-yl]-, (5R)-
- 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadienyl]-, (5R)-
- 3(2H)-thiophenone, 5-hydroxy-2,4-dimethyl-2-[(1E)-2-methyl-1,3-butadien-1-yl]-, (2R)-
- Antibiotic 2-200
Description:
Applications (R)-(+)-Thiolactomycin is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
210.29
Formula:
C11H14O2S
Color/Form:
Off White To Light Beige
InChI:
InChI=1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,12H,1H2,2-4H3/b7-6+/t11-/m1/s1
InChI key:
InChIKey=SYQNUQSGEWNWKV-JMEBYUIHSA-N
SMILES:
C=C/C(C)=C\[C@@]1(C)SC(=O)C(C)=C1O
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:
Technical inquiry about: TR-T350880 (R)-(+)-Thiolactomycin
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