D-Thyroxine

CAS: 51-49-0

Ref. TR-T425605

Product Information

• Name: D-Thyroxine
• Synonyms: D-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, Thyroxine, D- (8CI), 3,3',5,5'-Tetraiodo-D-thyronine, D-T4, Dextrothyroxine
• Brand: TRC

Description

Applications One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976), Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988), Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996), Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997),

Chemical properties

• Molecular weight: 776.87
• Formula: C₁₅H₁₁I₄NO₄
• Color/Form: Neat
• InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
• InChI key: InChIKey=XUIIKFGFIJCVMT-GFCCVEGCSA-N
• SMILES: N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O