Estimated delivery in United States, on Tuesday 28 May 2024
Product Information
Name:
Tivozanib
Controlled Product
Synonyms:
- Urea
- N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-
- N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea
- AV 951
- KRN 951
- Kil 8951
- N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea
- 1-[2-Chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
- Av-951
- Fotivda
- See more synonyms
- Krn 951
- N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N′-(5-methyl-3-isoxazolyl)urea
- Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N′-(5-methyl-3-isoxazolyl)-
CAS:
Description:
Applications Tivozanib is known as an oral VEGF receptor tyrosine kinase inhibitor, exhibiting antitumor effects towards renal cell carcinoma.. Tivozanib suppresses angiogenesis by selectively inhibiting against vascular endothelial growth factor. Potent VEGFR inhibitor.
References Nosov, D.A., et al.: J. Clinical. Oncol., 30, 1678 (2012); Pal, S.K., et al., Molec. Cancer. Thr, 11, 526 (2012);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
454.86
Formula:
C22H19ClN4O5
Color/Form:
Pale Beige to Light Brown Solid
InChI:
InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
InChI key:
InChIKey=SPMVMDHWKHCIDT-UHFFFAOYSA-N
SMILES:
COc1cc2nccc(Oc3ccc(NC(=O)N=c4cc(C)o[nH]4)c(Cl)c3)c2cc1OC
MDL:
Melting point:
Boiling point:
Flash point:
Density:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-T447205 Tivozanib
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