p-Toluoyl Chloride

CAS: 874-60-2

Ref. TR-T536400

Product Information

• Name: p-Toluoyl Chloride
• Synonyms: 4-Methylbenzoyl Chloride, 4-Methylbenzenecarbonyl Chloride, 4-Methylbenzoic Acid Chloride, 4-Methylbenzoyl Chloride, 4-Toluoyl Chloride, p-Methylbenzoyl Chloride, p-Toluic Acid Chloride, p-Toluyl Chloride
• Brand: TRC

Description

Applications p-Toluoyl chloride is an aromatic compound used as a reagent to synthesize (+)-Yashabushitriol, a plant metabolite that is naturally found in the male flowers of Alnus sieboldiana matsum. p-Toluoyl chloride is also used as a reagent to prepare derivatives of Desloratadine (D290250). Desloratadine is a selective H1-receptor antagonist that has anti-inflammatory effects and is used to treat patients with allergic rhinitis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Berger, W.. et al.: Ann. All. Asth. Immun., 89, 485 (2002); Fang, Z., et al.: Tetrahedron Lett., 54, 6834 (2013); Feldman, K. & Simpson, R.: Tetrahedron Lett., 30, 6985 (1989); Mu, S., et al.: Chin. Chem. Lett., 24, 531 (2013)

Chemical properties

• Molecular weight: 154.59
• Formula: C₈H₇ClO
• Color/Form: Neat
• InChI: InChI=1S/C8H7ClO/c1-6-2-4-7(5-3-6)8(9)10/h2-5H,1H3
• InChI key: InChIKey=QGZKDVFQNNGYKY-UHFFFAOYSA-N
• SMILES: Cc1cc2n(c(=O)c1C#N)CCC21OCCO1