Tolvaptan-d7

CAS: 1246818-18-7

Ref. TR-T536652

Product Information

• Name: Tolvaptan-d7
• Synonyms: N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide-d7, OPC 41061-d7

Description

Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),

• Brand: TRC

Chemical properties

• Molecular weight: 455.98
• Formula: C₂₆H₁₈D₇ClN₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)/i1D3,3D,4D,6D,7D
• InChI key: InChIKey=GYHCTFXIZSNGJT-FFQSSJIFSA-N
• SMILES: [2H]c1c([2H])c([2H])c(C([2H])([2H])[2H])c(C(=O)Nc2ccc(C(=O)N3CCCC(O)c4cc(Cl)ccc43)c(C)c2)c1[2H]