N-α-Tosyl-L-phenylalanylchloromethane

CAS: 402-71-1

Ref. TR-T686000

Product Information

• Name: N-α-Tosyl-L-phenylalanylchloromethane
• Synonyms: N-alpha-Tosyl-L-phenylalanylchloromethane, (S)-N-(4-Chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide, <span class="text-smallcaps">L</span>-1-Chloro-3-tosylamidyl-4-phenyl-2-butanone, <span class="text-smallcaps">L</span>-1-Chloro-4-phenyl-3-p-tolylsulfonamidobutan-2-one, <span class="text-smallcaps">L</span>-1-Chloro-4-phenyl-3-toluene-p-sulfonamido-2-butanone, <span class="text-smallcaps">L</span>-1-Tosylamide-2-phenylethylchloromethyl ketone, <span class="text-smallcaps">L</span>-1-Tosylamido-2-phenylethyl chloromethyl ketone, <span class="text-smallcaps">L</span>-Tolylsulfonylphenylalanyl chloromethyl ketone, Benzenesulfonamide, N-((1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-, Brn 2895215, L-1-Tosylamido-2-phenylethyl chloromethyl ketone, N-(4-chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide, N-(p-Toluenesulfonyl)-<span class="text-smallcaps">L</span>-phenylalanylchloromethane, N-Tosyl-<span class="text-smallcaps">L</span>-phenylalaninechloromethane, N-Tosyl-<span class="text-smallcaps">L</span>-phenylalanyl chloromethyl ketone, N-Tosyl-<span class="text-smallcaps">L</span>-phenylalanylchloromethane, N-Tosyl-L-phenylalanine chloromethyl ketone, N-Tosyl-L-phenylalanyl Chloromethyl Ketone, N-Tosylphenylalanine chloromethyl ketone, N-[(1S)-3-Chloro-2-oxo-1-(phenylmethyl)propyl]-4-methylbenzenesulfonamide, N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide, N-α-Tosyl-<span class="text-smallcaps">L</span>-phenylalanylchloromethane, N^α-Tosyl-<span class="text-smallcaps">L</span>-phenylalanine chloromethyl ketone, Tosylphenylalanine chloromethyl ketone, Tosylphenylalanyl chloromethyl ketone, Tosylphenylalanylchloromethane, Tpck, l-N-(alpha-(Chloroacetyl)phenethyl)-p-toluenesulfonamide, p-Toluenesulfonamide, N-(alpha-(chloroacetyl)phenethyl)-, (-)-, p-Toluenesulfonamide, N-[α-(chloroacetyl)phenethyl]-, <span class="text-smallcaps">L</span>-, α-N-Tosyl-<span class="text-smallcaps">L</span>-phenylalanine chloromethyl ketone, p-Toluenesulfonamide, N-[α-(chloroacetyl)phenethyl]-, L-, N-Tosyl-L-phenylalanylchloromethane

Description

Applications N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.
References Jitkaew, S. et al.: J. Bio. Chem., 284, 27827 (2009); Kim, K. et al.: Biochem. Biophys. Res. Comm., 306, 954 (2003); Griscavage, J. et al.: Biochem. Biophys. Res. Comm., 215, 721 (1995)

• Brand: TRC

Chemical properties

• Molecular weight: 351.848
• Formula: C₁₇H₁₈ClNO₃S
• Color/Form: Neat
• InChI: InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1