Estimated delivery in United States, on Monday 17 Jun 2024
Product Information
Name:
TPCA-1
Synonyms:
- 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
- 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxylic acid amide
- IKK 2 Inhibitor IV
- 2-((Aminocarbonyl)Amino)-5-(4-Fluorophenyl)-3-Thiophenecarboxamide
- 3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-
CAS:
Description:
Applications TPCA-1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCA-1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.
References Nan, J., et al.: Mol. Cancer Ther., 13, 617 (2014); Birrell, M.A., et al.: Am. J. Respir. Crit. Care Med., 172, 962 (2005); Birrell, M.A., et al.: Mol. Pharmacol., 69, 1791 (2006)
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
279.2901
Formula:
C12H10FN3O2S
Color/Form:
Light Beige Solid
InChI:
InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
InChI key:
InChIKey=UFQNQEIAGBZCBL-YOEHRIQHSA-N
SMILES:
COc1ccc2c3c1O[C@H]1CC(=O)CC[C@@]31CCN(C)C2
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-T700500 TPCA-1
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