Transplatin

CAS: 14913-33-8

Ref. TR-T714800

Product Information

• Name: Transplatin
• Synonyms: (SP-4-1)-Diamminedichloro-platinum, trans-Diamminedichloro-platinum, NSC 131558, trans-DDP, trans-Diaminedichloroplatinum, trans-Diamminedichloroplatinum, trans-Diamminedichloroplatinum(II), trans-Dichlorodiamineplatinum(II), trans-Dichlorodiammine platinum, trans-Dichlorodiammineplatinum(II), trans-Platinum(II) ammonium chloride, trans-Platinumdiammine dichloride, (SP-4-1)-Diamminedichloroplatinum, Diamminedichloro-Platinu(Sp-4-1), Dichlorodiamineplatinum(Ii), Nsc131558, Platinum(2+) Chloride Ammoniate (1:2:2), Platinum(4+) Chloride Azanide (1:2:2), Platinum, diamminedichloro-, (SP-4-1)-, Platinum, diamminedichloro-, trans-, Trans-Diaminedichloroplatinum, Trans-Diamminedichloroplatinum, Trans-Dichlorodiammineplatinum, Trans-Platinumdiamminedichloride

Description

Applications Transplatin is the trans stereoisomer impurity of Cisplatin (C499500), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.
References Cersosimo, R.J.: Cancer Treat. Rev., 16, 195 (1989); Takeiri, A. et al.: Genes Environ., 29, 89 (2007); Giraud-Panis, M.-J. et al.: Pharmacol. Therap., 85, 175 (2000);

• Brand: TRC

Chemical properties

• Molecular weight: 300.04
• Formula: Cl₂H₆N₂Pt
• Color/Form: Light Yellow
• InChI: +2/p-2, , , 2*1H3, /q, , InChI=1S/2ClH.2H3N.Pt/h2*1H
• SMILES: [Cl-].[Cl-].[NH2-].[NH2-].[Pt+4]