Triciribine

CAS: 35943-35-2

Ref. TR-T774245

Product Information

• Name: Triciribine
• Synonyms: 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine, 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 1,4,5,6,8-pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-, 1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pentaazaacennaphthylen-3-amine, 1,5-Dihydro-5-methyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine, 35943-35-2, 5-Methyl-1-Pentofuranosyl-1,5-Dihydro-1,4,5,6,8-Pentaazaacenaphthylen-3-Amine, 5-Methyl-1-b-D-ribofuranosyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, 5-methyl-1-(beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, 6-Amino-4-methyl-8-(β-<span class="text-smallcaps">D</span>-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine, AKT Inhibitor V, Api-2, NSC 154020, Triciribidine

Description

Applications Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
References Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011); Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (1998); Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (1978);

• Brand: TRC

Chemical properties

• Molecular weight: 320.30
• Formula: C₁₃H₁₆N₆O₄
• Color/Form: Neat
• InChI: InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
• InChI key: InChIKey=HOGVTUZUJGHKPL-HTVVRFAVSA-N
• SMILES: CN1NC(=N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c3ncnc1c23