4,4,4-Trifluoro-1-(4-fluorophenyl)butane-1,3-dione

CAS: 582-65-0

Ref. TR-T787100

Product Information

• Name: 4,4,4-Trifluoro-1-(4-fluorophenyl)butane-1,3-dione
• Synonyms: 1,3-Butanedione, 4,4,4-trifluoro-1-(p-fluorophenyl)- (6CI, 8CI), 4,4,4-Trifluoro-1-(4-fluorophenyl)-1,3-butanedione (ACI), 1,1,1-Trifluoro-4-(4-fluorophenyl)-2,4-butanedione, 1-(4-Fluorophenyl)-4,4,4-trifluoro-1,3-butanedione, 1-(4'-Fluorophenyl)-4,4,4-trifluoro-1,3-butanedione, 1,3-Butanedione, 4,4,4-trifluoro-1-(4-fluorophenyl)-

Description

Applications 4,4,4-Trifluoro-1-(4-fluorophenyl)butane-1,3-dioneis an intermediate in the synthesis of Mavacoxib (M197900) which is a long-acting COX-2 Inhibitor and is developed as a veterinary drug used to treat pain and inflammation with degenerative joint disease for dogs.
References Cox, S.R., et al.: J. Veterinary. Pharmacol. Therap., 33, 461 (2010); Chopra, M., et al.: J. Molec. Model., 14, 1087 (2008); Amaravani, M., et al.: Indian. J. Chem., Inorg. Bio-Iorg. Phy.Chem., 45, 174 (2006);

• Brand: TRC

Chemical properties

• Molecular weight: 234.15
• Formula: C₁₀H₆F₄O₂
• Color/Form: Neat
• InChI: InChI=1S/C10H6F4O2/c11-7-3-1-6(2-4-7)8(15)5-9(16)10(12,13)14/h1-4H,5H2
• SMILES: Cc1n2c(c[n+]1[O-])C[N+]([O-])=C(c1ccccc1F)c1cc(Cl)ccc1-2