(6R)-5,6,7,8-Tetrahydrobiopterin Dihydrochloride

CAS: 69056-38-8

Ref. TR-T795613

Product Information

• Name: (6R)-5,6,7,8-Tetrahydrobiopterin Dihydrochloride
• Synonyms: BioMarin T 1401, Biopten, Kuvan, SUN 0588, Sapropterin Dihydrochloride, Shiratori SN 0588, (6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride, (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride, (6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride, (6R)-Tetrahydrobiopterin hydrochloride, (6β)-5,6,7,8-Tetrahydro-<span class="text-smallcaps">L</span>-biopterin dihydrochloride, 2-amino-6-[(2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride, 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, dihydrochloride, [6R-[6R*(1R*,2S*)]]-, 4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, dihydrochloride, (6R)-, 4(1H)-Pteridinone, 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-, dihydrochloride, (6R-(6R*(1R*,2S*)))-, 4(3H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, hydrochloride (1:2), (6R)-, Sapropterin HCl, Sapropterin hydrochloride, Sun 0588, T1401, Unii-Rg277Lf5B3

Description

Stability Hygroscopic
Applications Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.
References Levy, Harvey L., et al.: Lancet, 370, 504 (2007); Isojima, Yasushi., et al.: Proc Natl Acad Sci USA .,106, 15744 (2009); Burton, B. K., et al.: J. Inherit. Metab. Dis., 30, 700 (2007)

• Brand: TRC

Chemical properties

• Molecular weight: 241.25 + 2(36.46)
• Formula: C₉H₁₅N₅O₃· 2(HCl)
• Color/Form: White To Off-White
• InChI: InChI=1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
• InChI key: InChIKey=RKSUYBCOVNCALL-NTVURLEBSA-N
• SMILES: C[C@H](O)[C@H](O)[C@H]1CNc2[nH]c(=N)[nH]c(=O)c2N1.Cl.Cl