2,2-Dimethylthiopropionamide

CAS: 630-22-8

Ref. TR-T796135

Product Information

• Name: 2,2-Dimethylthiopropionamide
• Synonyms: Dabrafenib related, GW 441956X, 2,2-Dimethylpropanethioamide, NSC 381432, Neopentanethioamide, Propanethioamide, 2,2-Dimethyl-, Propionamide, 2,2-dimethylthio-, Thiopivalamide

Description

Applications 2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
References Carter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013);

• Brand: TRC

Chemical properties

• Molecular weight: 117.21
• Formula: C₅H₁₁NS
• Color/Form: White
• InChI: InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7)
• InChI key: InChIKey=FJZJUSOFGBXHCV-UHFFFAOYSA-N
• SMILES: CC(C)(C)C(N)=S