D-erythro-N,N,N-Trimethylsphingosine Chloride

CAS: 134962-48-4

Ref. TR-T797150

Product Information

• Name: D-erythro-N,N,N-Trimethylsphingosine Chloride
• Synonyms: [(E,2R,3S)-1,3-dihydroxyoctadec-4-en-2-yl]-trimethylazanium;chloride
• Brand: TRC

Description

Stability Store in Freezer
Applications Has an inhibitory effect via blocking of transmembrane signaling on the growth of various human tumor cell lines in vitro as well as in vivo in nu/nu mice. A potent and effective cardioprotective agent that inhibits leukocyte-endothelial cell interactions and preserves cardiac contractile function and coronary perfusion following myocardial ischemia and reperfusion.
References Handa, K., et al.: Biochemistry, 30, 50, 11684 (1991), Endo, K., et al.: Cancer Research, 51, 1613 (1991), Park, Y.S., et al.: Cancer Research, 54, 2213 (1994), Kennedy, S.D., et al.: Am. J. Clin. Pathol., 107, 1, 99 (1997), Campbell, B., et al: Cardivasc. Res., 39, 2, 393 (1998),

Chemical properties

• Molecular weight: 378.03
• Formula: C₂₁H₄₄NO₂·Cl
• Color/Form: Neat
• InChI: InChI=1S/C21H44NO2.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21(24)20(19-23)22(2,3)4;/h17-18,20-21,23-24H,5-16,19H2,1-4H3;1H/q+1;/p-1/b18-17+;/t20-,21+;/m1./s1
• SMILES: CCCCCCCCCCCCC/C=C\[C@@H](O)C(CO)[N+](C)(C)C.[Cl-]