S-Trityl-L-cysteine

CAS: 2799-07-7

Ref. TR-T887350

Product Information

• Name: S-Trityl-L-cysteine
• Synonyms: (2R)-2-amino-3-tritylsulfanylpropanoic acid, (2R)-2-Amino-3-[(triphenylmethyl)sulfanyl]propanoic acid, (2R)-2-Amino-3-[(triphenylmethyl)thio]propanoic acid, (2R)-2-Azaniumyl-3-tritylsulfanylpropanoate, 3-Tritylthio-<span class="text-smallcaps">L</span>-alanine, <span class="text-smallcaps">L</span>-Cysteine, S-(triphenylmethyl)-, Alanine, 3-(tritylthio)-, <span class="text-smallcaps">L</span>-, H-Cys(Trt)-OH, NSC 83265, S-(Triphenylmethyl)-<span class="text-smallcaps">L</span>-cysteine, S-Triphenylmethyl-L-cysteine, S-Trityl-(R)-cysteine, S-Trityl-<span class="text-smallcaps">L</span>-cysteine, S-tritylcysteine, Tritylthioalanine, L-Cysteine, S-(triphenylmethyl)-, Alanine, 3-(tritylthio)-, L-

Description

Applications A protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.
References Brier, S., et al.: Biochemistry, 43, 13072 (2004), Sakowicz, R., et al.: Cancer Res., 64, 3276 (2004), Zhu, C., et al.: Mol. Biol. Cell, 16, 3187 (2005),

• Brand: TRC

Chemical properties

• Molecular weight: 363.47
• Formula: C₂₂H₂₁NO₂S
• Color/Form: Neat
• InChI: InChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1
• InChI key: InChIKey=DLMYFMLKORXJPO-FQEVSTJZSA-N
• SMILES: N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O