25R-3α,7α,12α-Trihydroxy-5β-cholestanoic Acid

CAS: 23740-14-9

Ref. TR-T887965

Product Information

• Name: 25R-3α,7α,12α-Trihydroxy-5β-cholestanoic Acid
• Synonyms: (25R)-3a,7a,12a-Trihydroxy-5ß-cholestan-26-oic Acid, (3a,5ß,7a,12a,25R)-3,7,12-Trihydroxy-5ß-cholestan-26-oic Acid

Description

Applications 25R-3α,7α,12α-Trihydroxy-5β-cholestanoic acid is an intermediate in the synthesis of (25R)-3β,7α,12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood.
References Schroepfer, G., et al.: Physiol. Rev., 80, 361 (2000); Bjorkhem, I.: J. Clin. Invest., 6, 725(2002); Bjorkhem, I., et al.: Arterio. hromb. Vascul. Biol., 22, 734 (2002)

• Brand: TRC

Chemical properties

• Molecular weight: 450.65
• Formula: C₂₇H₄₆O₅
• Color/Form: Neat
• InChI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16-,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1
• InChI key: InChIKey=CNWPIIOQKZNXBB-WBYPBBSPSA-N
• SMILES: C[C@H](CCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O