(3β,5β,7α,12α,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid

Ref. TR-T887995

Product Information

• Name: (3β,5β,7α,12α,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid

Description

Applications (3β,5β,7α,12α,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid is an intermediate in the synthesis of (25R)-3β,7α,12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood.
References Schroepfer, G., et al.: Physiol. Rev., 80, 361 (2000); Bjorkhem, I.: J. Clin. Invest., 6, 725(2002); Bjorkhem, I., et al.: Arterio. hromb. Vascul. Biol., 22, 734 (2002)

• Brand: TRC

Chemical properties

• Molecular weight: 448.64
• Formula: C₂₇H₄₄O₅
• Color/Form: Neat
• InChI: InChI=1S/C27H44O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h7,15,17-24,28-30H,5-6,8-14H2,1-4H3,(H,31,32)/b16-7+/t15-,17+,18+,19-,20?,21?,22-,23+,24?,26+,27-/m1/s1
• InChI key: InChIKey=VXQOOUCCLSSSSV-VKELCSSASA-N
• SMILES: C/C(=C\CC[C@@H](C)[C@H]1CCC2C3C(C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@H](O)C[C@H]1C[C@H]3O)C(=O)O