Product Information
Name:3-(N-1-Trityl-imidazol-4-yl)propionic Acid
Controlled Product
Synonyms:
- N-1-Trityl-deamino-histidine (3-(N-1-Trityl-imidazol-4-yl)propionic acid N-1-Trityl-dihydrourocanic Acid
- 1-(Triphenylmethyl)-1H-imidazole-4-propanoic Acid
- Deamino-His(Trt)-OH
- 3-(1-Tritylimidazol-4-yl)propionic Acid
Brand:TRC
Description:Applications 3-(N-1-Trityl-imidazol-4-yl)propionic Acid is an intermediate used to prepare imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase. It is also used in the synthesis of nonracemic arylpiperazinone analogs of the carboxyl-terminal CAAL sequence of protein geranylgeranyltransferase-I (PGGTase-I) as selective inhibitors of PGGTase-I and of protein farnesyltransferase.References Ding, C., et al.: J. Med. Chem., 42, 5241 (1999); Peng, H., et al.: Org. BIomol. Chem., 4, 1768 (2006)
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Chemical properties
Molecular weight:382.45
Formula:C25H22N2O2
Color/Form:Neat
InChI:InChI=1S/C25H22N2O2/c28-24(29)17-16-23-18-27(19-26-23)25(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-15,18-19H,16-17H2,(H,28,29)
InChI key:InChIKey=WPUNOGRJNPUUQT-UHFFFAOYSA-N
SMILES:O=C(O)CCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1
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