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URB754
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URB754

CAS: 86672-58-4

Ref. TR-U822000

5mg
92.00 €
10mg
94.00 €
25mg
180.00 €
Estimated delivery in United States, on Tuesday 3 Dec 2024

Product Information

Name:
URB754
Controlled Product
Synonyms:
  • 6-methyl-2-(4-methylanilino)-3,1-benzoxazin-4-one
  • 4H-3,1-Benzoxazin-4-one, 6-methyl-2-[(4-methylphenyl)amino]-
  • 6-methyl-2-(4-toluidino)-4H-3,1-benzoxazin-4-one
  • Urb 754
  • Urb754
Description:

Applications URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 µM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 µM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 µM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
References Makara, J.K., et al.: Nat. Neurosci., 8, 1139 (2005)

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
266.29
Formula:
C16H14N2O2
Color/Form:
Neat
InChI:
InChI=1S/C16H14N2O2/c1-10-3-6-12(7-4-10)17-16-18-14-8-5-11(2)9-13(14)15(19)20-16/h3-9H,1-2H3,(H,17,18)
InChI key:
InChIKey=GFWNGVKCDGYFKG-UHFFFAOYSA-N
SMILES:
Cc1ccc(Nc2nc3ccc(C)cc3c(=O)o2)cc1
MDL:
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EINECS:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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